师资队伍

全职教师
访问教授

Full-time teachers

全职教师
  • 姓 名:刘滨
  • 职 称:教授、博导
  • 职 务:
  • 邮 件:bliu@hit.edu.cn,binliu.hitsz@foxmail.com
  • 研究方向:生物信息学、机器学习、自然语言处理、人工智能、数据挖掘
  • 电 话:
  • 个人主页:http://www.hitsz.edu.cn/teacher/view/id-739.html
  • 通讯地址:
教育经历
2007/03-2010/08
哈尔滨工业大学深圳研究生院,计算机科学与技术学院,工学博士
2004/09-2007/03
哈尔滨工程大学,计算机科学与技术学院,工学硕士
2000/09 -2004/06
哈尔滨工程大学,计算机科学与技术学院,工学学士
工作经历
2015/05至今
哈尔滨工业大学深圳研究生院,计算机科学与技术学院,博士生导师(破格)
2014/08至今
哈尔滨工业大学深圳研究生院,计算机科学与技术学院,副教授
2012/01-2014/07
哈尔滨工业大学深圳研究生院,计算机科学与技术学院,助理教授
2010/12-2012/01
美国俄亥俄州立大学,生物信息系,博士后
科研项目
2014.1-2016.12
基于序列谱进化信息的蛋白质远程同源性检测方法研究,国家自然科学基金青年基金,主持
2013.1-2016.12
面向真实环境的异构信息交互式问答理论与方法研究, 国家自然科学基金面上项目,第一参与人
2012.10-2014.10
固有无序蛋白质预测技术研究,广东省自然科学基金博士启动,主持
2013.1-2014.12
哈工大科研创新基金,主持
2012.3-2014.3
深研院新教师科研启动项目,主持
2012.12-2014.12
上海市智能信息处理重点实验室开放课题,主持
2014
教育部留学回国人员科研启动基金,主持
2014
广东省自然科学基金自由申请项目,主持
发表论文


在《Nature Cell Biology》(影响因子20.058)、《Nucleic Acids Research》(影响因子8.808)、《Bioinformatics》(影响因子4.621)等著名国际期刊发表学术论文41篇,其中SCI检索论文23篇,总影响因子大于95,其中第一作者和通讯作者论文21篇,总引用次数380余次, 其中3篇论文为ESI高引论文,1篇论文为热点论文(hot paper)。更多信息请见生物信息学研究组主页:http://bioinformatics.hitsz.edu.cn/ 

代表作 

Bin Liu*, Fule Liu, Xiaolong Wang, Junjie Chen, Longyun Fang, Kuo-Chen Chou*: Pse-in-One: a web server for generating various modes of pseudo components of DNA, RNA, and protein sequences. Nucleic Acids Research 2015:doi: 10.1093/nar/gkv458. (In Press, SCI, 影响因子: 8.808, JCR 1区) 

Bin Liu*, Fule Liu, Longyun Fang, Xiaolong Wang, Kuo-Chen Chou*, repDNA: a Python package to generate various modes of feature vectors for DNA sequences by incorporating user-defined physi-cochemical properties and sequence-order effects, Bioinformatics, 2015, 31(8):1307-1309.. (SCI, 影响因子: 4.621, JCR 1区) 

Bin Liu*, Deyuan Zhang, Ruifeng Xu, Jinghao Xu, Xiaolong Wang, Qingcai Chen, Qiwen Dong, Kuo-Chen Chou, Combining evolutionary information extracted from frequency profiles with sequence-based kernels for protein remote homology detection. Bioinformatics, 2014, 30(4): 472-479. (SCI, 影响因子5.323, JCR 1区, ESI高引论文) 

HuiZi Chen, Madhu M. Ouseph, Jing Li, Thierry Pecot, Veda Chokshi, Lindsey Kent, Sooin Bae, Morgan Byrne, Camille Duran, Grant Comstock, Prashant Trikha, Markus Mair, Shantibhusan Senapati, Chelsea K. Martin, Sagar Gandhi, Nicholas Wilson, Bin Liu, YiWen Huang, John C. Thompson, Sundaresan Raman, Shantanu Singh, Marcelo Leone, Raghu Machiraju, Kun Huang, Xiaokui Mo, Soledad Fernandez, llona Kalaszczynska, Debra J. Wolgemuth, Piotr Sicinski, Tim Huang, Victor Jin and Gustavo Leone, Canonical and Atypical E2Fs Regulate the Mammalian Endocycle. Nature Cell Biology, 14 (11), pp. 1192-1202, 2012 (SCI, 影响因子19.488, JCR 1区) 

Bin Liu, Jimmy Yi, Aishwarya SV, Xun Lan, Yilin Ma, Michael Ostrowski, Gustavo Leone, and Victor X. Jin*, QChIPat: a quantitative method to identify distinct binding patterns for two biological ChIP-seq samples in different experimental conditions. BMC Genomics, 2013, 14(Suppl 8):S3. (SCI, 影响因子4.4,JCR 1区) 

Bin Liu*, Longyun Fang, Fule Liu, Xiaolong Wang, Junjie Chen, Kuo-Chen Chou,Identification of real microRNA precursors with a pseudo structure status composition approach, PLoS ONE,2015, 10(3):e0121501.(SCI,影响因子: 3.534, JCR1区) 

Bin Liu*, Xiaolong Wang, Qingcai Chen, Qiwen Dong and Xun Lan, Using amino acid physicochemical distance transformation for fast protein remote homology detection, PLoS ONE, 7 (9): e46633, 2012 (SCI, 影响因子4.092, JCR1区) 

Bin Liu*, Jinghao Xu, Xun Lan, Ruifeng Xu, Jiyun Zhou, Xiaolong Wang, Kuo-Chen Chou*, iDNA-Prot|dis: identifying DNA-binding proteins by incorporating amino acid distance-pairs and reduced alphabet profile into the general pseudo amino acid composition, PLoS ONE, 2014 9(9): e106691 (SCI, impact factor: 3.534, JCR1区) 

Bin Liu, Jinghao Xu, Quan Zou, Ruifeng Xu*, Xiaolong Wang and Qingcai Chen, Using distances between Top-n-gram and residue pairs for protein remote homology detection. BMC Bioinformatics, 2014, 15(Suppl 2):S3 (SCI, 影响因子3.02,JCR 2区) 

Bin Liu*, Xiaolong Wang, Lei Lin, Qiwen Dong and Xuan Wang, A discriminative method for protein remote homology detection and fold recognition combining Top-n-grams and latent semantic analysis. BMC Bioinformatics, 9: 510, 2008 (SCI, 影响因子3.781,JCR 1区) 

Bin Liu*, Xiaolong Wang, Lei Lin, Buzhou Tang, Qiwen Dong and Xuan Wang, Prediction of protein binding sites in protein structures using hidden Markov support vector machine. BMC Bioinformatics, 10: 381, 2009 (SCI, 影响因子3.482,JCR 2区) 

Bin Liu*, Longyun Fang, Chenjun Jie, Fule Liu, Xiaolong Wang, miRNA-dis: microRNA precursor identification based on distance structure status pairs, Molecular BioSystems, 2015, 11:1194-1204. ( SCI,影响因子:3.183) 

Bin Liu*, Longyun Fang, Fule Liu, Xiaolong Wang, Kuo-Chen Chou, iMiRNA-PseDPC: microRNA precursor identification with a pseudo distance-pair composition approach, Journal of Biomolecular Structure & Dynamics.DOI: 10.1080/07391102.07392015.01014422. (In Press, SCI,影响因子2.983,JCR2区) 

Bin Liu*, Chenjun Jie, Xiaolong Wang, Protein remote homology detection by combining Chou’s distance-pair pseudo amino acid composition and principal component analysis, Molecular Genetics and Genomics, :DOI: 10.1007/s00438-00015-01044-00434. (in press, SCI,影响因子:2.831 ) 

Bin Liu*, Xiaolong Wang, Quan Zou, Qiwen Dong, Qingcai Chen, Protein remote homology detection by combining Chou’s pseudo amino acid composition and profile-based protein representation. Molecular Informatics, 32, pp 775-782, 2013 (SCI, 影响因子2.39,JCR 2区) 

Bin Liu*, Jinghao Xu, Shixi Fan, Ruifeng Xu, Jiyun Zhou, Xiaolong Wang, PseDNA-Pro: DNA-binding Protein Identification by Combining Chou’s PseAAC and Physicochemical Distance Transformation. Molecular Informatics. 2015 34(1): 8-17. (SCI, impact factor: 2.39, JCR 2区) 

Bin Liu*, Bingquan Liu, Fule Liu, Xiaolong Wang, Protein binding site prediction by combining Hidden Markov Support Vector Machine and Profile-based Propensities, The Scientific World Journal, 2014(2014): 464093(SCI, impact factor: 1.74) 

Bin Liu*, Xiaolong Wang, Lei Lin, Qiwen Dong and Xuan Wang, Exploiting three kinds of interface propensities to identify protein binding sites. Computational Biology and Chemistry, 33 (4), pp. 303-311, 2009 (EI, SCI, 影响因子1.370,JCR 3区) 

Ruifeng Xu, Jiyun Zhou, Bin Liu*, Lin Yao, Yulan He, Quan Zou and Xiaolong Wang, enDNA-Prot: Identification of DNA-binding Proteins by Applying Ensemble Learning. BioMed Research International (accepted, SCI, impact factor: 2.88,*通讯作者) 

Y. Zhang, Bin Liu*, Qiwen Dong, Victor X. Jin, An improved profile-level domain linker propensity index for protein domain boundary prediction. Protein and Peptide Letters, 18 (1), pp 7-16, 2011 (SCI, 影响因子1.942,JCR 3区,通讯作者) 

Quan Zou, Zhen Wang, Yunfeng Wu, Bin Liu, Ziyu Lin and Xinjun Guan, An Approach for Identifying Cytokines Based On a Novel Ensemble Classifier. BioMed Research International, 2013: 686090, 2013 (SCI, 影响因子2.880) 

Ruifeng Xu, Jiyun Zhou, Bin Liu*, Yulan He, Quan Zou, Xiaolong Wang, Kuo-Chen Chou, Identification of DNA-binding proteins by incorporating evolutionary information into pseudo amino acid composition via the top-n-gram approach, Journal of Biomolecular Structure and Dynamics. (SCI, 影响因子: 2.983, JCR2区, 通讯作者) 

Ruifeng Xu, Jiyun Zhou, Hongpeng Wang, Yulan He, Xiaolong Wang, Bin Liu*, Identifying DNA-binding proteins by combining support vector machine and PSSM distance transformation, BMC Systems Biology. (Accepted, Special Issue of APBC 2015, SCI,影响因子: 2.853, JCR1区,通讯作者) 

Bin Liu*, Xiaolong Wang, Ruifeng Xu, Buzhou Tang, Protein remote homology detection by combining profile-based protein representation with local alignment kernel, Journal of Medical and Bioengineering, 3(1), pp 17-22, 2013. 

Bin Liu*, Xiaolong Wang. Using Chou’s pseudo amino acid composition for protein remote homology detection, Engineering, 5, pp 149-153, 2013. 

Lei. Lin, Bin Liu*, Xiaolong Wang, Xuan Wang, Buzhou Tang, Protein Remote Homology Detection and Fold Recognition based on Features Extracted from Frequency Profiles. Journal of Computers, 6 (2), pp. 321-328, 2011 (EI,通讯作者)

Lei Lin, Yi Shen, Bin Liu, Xiaolong Wang, Protein Fold Recognition and Remote Homology Detection Based on Profile-level Building Blocks. International Conference on Biomedical Engineering and Computer Science (ICBECS2010), April 23-25, Wuhan, China, 2010. ( EI) 

Bin Liu, Lei Lin, Xiaolong Wang and Xuan Wang, Protein remote homology detection using order profiles. 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing (IJCBS'09), 2009, pp. 255-260, Aug. 3-5, Shanghai, China (EI) 

Bin Liu, Lei Lin, Xiaolong Wang, Qiwen Dong and Xuan Wang, A Discriminative Method for Protein Remote Homology Detection Based on N-nary Profiles, Bioinformatics Research and Development 2008 (BIRD2008), pp. 74-86, July 7-9, Vienna, Austria, 2008. 

Bin Liu, Lei Lin, Xiaolong Wang and Xuan Wang, Yi Shen, Protein long disordered region prediction based on profile-level disorder propensities and position-specific scoring matrixes. 2009 IEEE International Conference on Bioinformatics and Biomedicine (BIBM09), pp. 66-69, Nov. 1-4, Washington D.C., USA, 2009. (EI) 

Lin Gui; Ruifeng Xu; Qin Lu; Jun Xu; Jian Xu; Bin Liu; Xiaolong Wang, Cross-lingual Opinion Analysis via Negative Transfer Detection, Proceedings of ACL 2014, pp.860-865

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